CAS NO: | 73029-73-9 |
包装: | 50mg, 100mg, 250mg |
规格: | ≥98% |
CyPPA is a positive modulator of SK3 and SK2, which reduces the activity of dopaminergic neurons. CyPPA inhibits dopamine release, and counteracts hyperdopaminergic behaviors induced by methylphenidate. References: Herrik KF, Redrobe JP, Holst D, Hougaard C, Sandager-Nielsen K, Nielsen AN, Ji H, Holst NM, Rasmussen HB, Nielsen EO, Strobaek D, Shepard PD, Christophersen P. CyPPA, a Positive SK3/SK2 Modulator, Reduces Activity of Dopaminergic Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate. Front Pharmacol. 2012 Feb 13;3:11. doi: 10.3389/fphar.2012.00011. eCollection 2012. PubMed PMID: 22347859; PubMed Central PMCID: PMC3278045. 2: Dolga AM, Letsche T, Gold M, Doti N, Bacher M, Chiamvimonvat N, Dodel R, Culmsee C. Activation of KCNN3/SK3/K(Ca)2.3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia. Glia. 2012 Dec;60(12):2050-64. doi: 10.1002/glia.22419. Epub 2012 Sep 21. PubMed PMID: 23002008; PubMed Central PMCID: PMC3799773.
纯度:≥98%
CAS:73029-73-9