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Fadraciclib | CYC065
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Fadraciclib | CYC065图片
CAS NO:1070790-89-4
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍

Fadraciclib (CYC-065) is a novel, 2nd generation, ATP-competitive and orally bioavailable inhibitor of cyclin dependent kinases 2, 5 and 9 (CDK2/5/9, IC50s of 5 and 26 nM for CDK2/9) with potential antineoplastic and chemoprotective activities. CYC065 selectively binds to and inhibits the activity of CDK2, 5 and 9, which leads to inhibition of CDK2, 5 and 9-dependent cellular pathways, downregulation of genes involved in the pro-survival pathway, prevention of the activation of DNA double-strand break repair pathways, and induction of both cell cycle arrest and apoptosis. This inhibits the proliferation of CDK2/5/9-overexpressing tumor cells. In addition, CYC065 protects hematopoietic stem and progenitor cells (HSPCs), prevents myelosuppression, and preserves the function of the bone marrow.

纯度:≥98%

CAS:1070790-89-4