生物活性
LY2801653 dihydrochloride是一种有效的，口服可生物利用的c-MET激酶小分子抑制剂（Ki = 2 nM）。
化学数据
| 目录号 | A15150 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 625.45 |
| Formula | C30H24Cl2F2N6O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 1206801-37-7 |
| Synonyms | LY-2801653 dihydrochloride, LY 2801653 dihydrochloride |
| SMILES | CC1=CC=C(C(=O)N1C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C(C=C5C(=C4)C=NN5C)C6=CNN=C6)F.Cl.Cl |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 15.99 mL | 79.94 mL | 159.88 mL |
| 0.5 mM | 3.2 mL | 15.99 mL | 31.98 mL |
| 1 mM | 1.6 mL | 7.99 mL | 15.99 mL |
| 5 mM | 0.32 mL | 1.6 mL | 3.2 mL |
*The above data is based on the productmolecular weight 625.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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