您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Pralatrexate,(R)-
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Pralatrexate,(R)-
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pralatrexate,(R)-图片
CAS NO:1320211-70-8
规格:≥98%
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议

产品介绍

Pralatrexate, (R)- is the R-enantiomer of Pralatrexate (also known as Folotyn), which is an antifolate which is structurally a folate analog, and is a potent inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate exhibits high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; it competes for the folate binding site of DHFR, blocking tetrahydrofolate synthesis, which may result in depletion of nucleotide precursors, inhibition of DNA/RNA/protein synthesis, and apoptotic tumor cell death.

纯度:≥98%

CAS:1320211-70-8