CAS NO: | 1610759-22-2 |
规格: | ≥98% |
包装 | 价格(元) |
2mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
CFI-402257 (CFI402257) is a novel, highly potent, orally bioavailable and selective inhibitor of TTK protein kinase (also known as Monopolar spindle 1 [Mps1]) activity with potential anticancer activity. It inhibits TTK with a Ki of 0.1 nM. TTK is an essential chromosomal regulator overexpressed in aneuploid tumors, and is important in regulating cell growth. High TTK levels correlate with a high tumor grade11 and poor patient outcomes. TTK inhibition are associated with a disabled mitotic checkpoint, resulting in chromosome segregation errors, aneuploidy, and cell death.
纯度:≥98%
CAS:1610759-22-2