CS1 is a potent inhibitor of microtubule polymerization via interaction with the colchicine-binding pocket of tubulin, inducing unique histone phosphorylation patterns distinct from those induced by colchicine. CS1 is an antimitotic. References: Wu X, Li Z, Shen Y. The small molecule CS1 inhibits mitosis and sister chromatid resolution in HeLa cells. Biochim Biophys Acta Gen Subj. 2018 May;1862(5):1134-1147. doi: 10.1016/j.bbagen.2018.01.012. Epub 2018 Feb 15. PubMed PMID: 29410075.
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CAS:1448009-94-6