CS-2100 is a potent, orally bioavailable and S1P3-sparing S1P1 agonist. CS-2100 had >5000-fold greater agonist activity for human S1P(1) (EC(50); 4.0 nM) relative to S1P(3) (EC(50); >20,000 nM). CS-2100 is efficacious in the adjuvant-induced arthritis model in rats (ID(50); 0.44 mg/kg). CS-2100 showed potent efficacy in various animal disease models, it was also revealed that the central 1,2,4-oxadiazole ring of CS-2100 was decomposed by enterobacteria in intestine of rats and monkeys, implicating the latent concern about an external susceptibility in its metabolic process in the upcoming clinical studies. References: Legnani C, Cini M, Frascaro M, Rodorigo G, Sartori M, Cosmi B. Diagnostic Accuracy of a New d-Dimer Assay (Sclavo Auto d-Dimer) for Exclusion of Deep Vein Thrombosis in Symptomatic Outpatients. Clin Appl Thromb Hemost. 2017 Apr;23(3):221-228. doi: 10.1177/1076029616649436. Epub 2016 Jul 9. PubMed PMID: 27193029.

纯度：≥98%

CAS：913827-99-3