CPUY192018 Disodium is a potent small-molecule inhibitor of the Keap1-Nrf2 PPI. CPUY192018 Disodium has a cytoprotective effect against DSS in both NCM460 cells and mouse colon via the activation of Nrf2 signaling. Activation of Nrf2 by directly inhibiting the Keap1-Nrf2 PPI may be beneficial as a treatment for ulcerative colitis. References: Lu MC, Ji JA, Jiang YL, Chen ZY, Yuan ZW, You QD, Jiang ZY. An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis. Sci Rep. 2016 May 24;6:26585. doi: 10.1038/srep26585. PubMed PMID: 27215610; PubMed Central PMCID: PMC4877580.

纯度：≥98%

CAS：1567836-15-0