CAS NO: | 1446399-26-3 |
包装: | 50mg, 100mg, 250mg |
规格: | ≥98% |
Cmpd-A is a time-dependent CENP-E inhibitor with potent antitumor activity. Cmpd-A inhibits the ATPase activity of the CENP-E motor domain, acting as a time-dependent inhibitor with an ATP-competitive-like behavior. Cmpd-A causes chromosome misalignment on the metaphase plate, leading to prolonged mitotic arrest. Treatment with Cmpd-A induces antiproliferation in multiple cancer cell lines. References: Ohashi A, Ohori M, Iwai K, Nambu T, Miyamoto M, Kawamoto T, Okaniwa M. A Novel Time-Dependent CENP-E Inhibitor with Potent Antitumor Activity. PLoS One. 2015 Dec 9;10(12):e0144675. doi: 10.1371/journal.pone.0144675. eCollection 2015. PubMed PMID: 26649895; PubMed Central PMCID: PMC4674098.
纯度:≥98%
CAS:1446399-26-3