Cizolirtine, formerly known as E-4018 (citrate salt) or E-3710, is a calcitonin gene-related peptide antagonist potentially for the treatment of pain, overactive. The efficacy of Cizolirtine has been demonstrated in various models of acute and inflammatory pain in rodents. Cizolirtine may be useful for alleviating some neuropathic somatosensory disorders, in particular cold allodynia, with a reduced risk of undesirable side effects.. Cizolirtine inhibits the spinal release of substance P and CGRP in rats. References: Costantini E, Lazzeri M. Editorial comment on: Cizolirtine citrate is safe and effective for treating urinary incontinence secondary to overactive bladder: a phase 2 proof-of-concept study. Eur Urol. 2010 Jan;57(1):152-3. doi: 10.1016/j.eururo.2009.04.046. Epub 2009 May 7. PubMed PMID: 19446952.

纯度：≥98%

CAS：251375-82-3