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Penpulimab
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CAS NO:2350298-92-7
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
Penpulimab 是一种 IgG1 抗 PD-1 单克隆抗体，具有抗肿瘤活性。
Cas No.2350298-92-7
别名派安普利单抗
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Penpulimab is an IgG1 backbone anti-PD-1monoclonal antibody with antitumor activities[1].

Penpulimab demonstrates better stability and a lower level of host-cell protein residue compared with IgG4 backbone anti-PD-1 antibodies[1].
Penpulimab does not mediate complement-dependent cytotoxicity (CDC) or antibody-dependent cell-mediated cytotoxicity (ADCC) and induces no remarkable IL-6 and IL-8 release by activated macrophages[1].
Penpulimab exhibits slower binding off-rate for human PD-1 than Nivolumab and Pembrolizumab[1].
Penpulimab potentiates T cell activation via PD-1/PD-L1 blockade[1].

Penpulimab (5 mg/kg; i.p.; twice a week, 3weeks) inhibits tumor growth in mice[2].

Animal Model:MC38-hPD-L1 tumor-bearing B-hPD-1 humanized mouse model[2]
Dosage:5 mg/kg
Administration:IP, twice a week, 3weeks
Result:Showed moderate inhibition of tumor growth (tumor volume: 58.4% of control group). Treatment combined with anlotinib (1 mg/kg, every day, p.o) significantly decreased tumor volume to 36.5% of control group.

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