| CAS NO: | 27958-06-1 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 25mg | 电议 |
| Cas No. | 27958-06-1 |
| 别名 | 脱乙酰茴香霉素 |
| Canonical SMILES | COC(C=C1)=CC=C1C[C@@H]2[C@H](O)[C@@H](O)CN2 |
| 分子式 | C12H17NO3 |
| 分子量 | 223.3 |
| 溶解度 | Methanol: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Deacetylanisomycin is a derivative of the protein and DNA synthesis inhibitor anisomycin with antimalarial and anticancer activity.1,2It inhibits the growth of theP. falciparumstrains K1 and T9-96in vitro(IC50s = 40.29 and 33.57 μM, respectively).1Deacetylanisomycin is cytotoxic to LU99 lung carcinoma and MCF-7 breast cancer cells (IC50s = 23 and 34 μM, respectively). It has been used as a negative control for assessment of protein synthesis inhibitor activity in molluscan neurons.3 1.Ekong, R.M., Kirby, G.C., Patel, G., et al.Comparison of the in vitro activities of quassinoids with activity against Plasmodium falciparum, anisomycin and some other inhibitors of eukaryotic protein synthesisBiochem. Pharmacol.40(2)297-301(1990) 2.Hosoya, Y., Kameyama, T., Naganawa, H., et al.Anisomycin and new congeners active against human tumor cell linesJ. Antibiot. (Tokyo)46(8)1300-1302(1993) 3.Alkon, D.L., Bank, B., Naito, S., et al.Inhibition of protein synthesis prolongs Ca2+-mediated reduction of K+ currents in molluscan neuronsProc. Natl. Acad. Sci. USA84(19)6948-6952(1987) |
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