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HIF-1α-IN-2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
HIF-1α-IN-2图片
CAS NO:2762315-06-8
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
HIF-1α-IN-2 是一种有效的 HIF-1α 抑制剂,具有抗癌作用,在 MDA-MB-231 和 MiaPaCa-2 细胞 IC50 中分别为 28 nM 和 15 nM。HIF-1α-IN-2 通过阻断转录和蛋白质翻译抑制来 HIF-1α 的表达。
Cas No.2762315-06-8
分子式C21H19N3OS
分子量361.46
储存条件4°C, away from moisture and light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

HIF-1α-IN-2 is an effectiveHIF-1αinhibitor with anticancer potencies (IC50s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2 suppresses HIF-1α expression by blocking transcription and protein translation[1].

HIF-1α-IN-2 (compound 7f) (5 μM; 72h) suppresses the viability of MDA-MB-231 and MiaPaCa-2 cells with IC50s of 28 nM and 15 nM, respectively[1].
HIF-1α-IN-2 (0-1 μM; 72h) suppresses the expression of HIF-1α and VEGF with dose-dependent effect[1].
HIF-1α-IN-2 (0.25, 0.5, and 1 µM; 16-24h) can significantly inhibit the migration of MDA-MD-231 cells by 56% (0.25 µM), 83% (0.5 µM), and 85% (1 µM), respectively, and also noted in MiaPaCa-2 cells, which demonstrates the unique anti-migration effect of HIF-1α-IN-2[1].
HIF-1α-IN-2 (0-1 μM; 72h) suppresses HIF-1α mRNA levels in MDA-MB-231 cells under hypoxia[1].

Cell Viability Assay

Cell Line:MDA-MB-231 cells, MiaPaCa-2 cells[1]
Concentration:5 μM
Incubation Time:72 hours
Result:Suppressed the viability of these two cell lines with IC50of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively.

Cell Viability Assay

Cell Line:MDA-MB-231 cells, MiaPaCa-2 cells[1]
Concentration:5 μM
Incubation Time:72 hours
Result:Suppressed the viability of these two cell lines with IC50of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively.