您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > PAD2-IN-1 hydrochloride
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
PAD2-IN-1 hydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
PAD2-IN-1 hydrochloride图片
包装:5mg
市场价:8550元

产品介绍
PAD2-IN-1 hydrochloride，一种基于苯并咪唑的衍生物，是一种有效的选择性蛋白精氨酸脱亚氨酶 2 (PAD2) 抑制剂。PAD2-IN-1 hydrochloride 对 PAD2 的选择性优于 PAD4 (95 倍) 和 PAD3 (79 倍)。
分子式C25H30ClFN6O3
分子量517
储存条件4°C, away from moisture and light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PAD2-IN-1 hydrochloride, a benzimidazole-based derivative, is a potent and selectiveprotein arginine deiminase 2 (PAD2)inhibitor. PAD2-IN-1 hydrochloride shows superior selectivity forPAD2over PAD4 (95-fold) and PAD3 (79-fold)[1].

In the target engagement assay, the EC50of PAD2-IN-1 (compound 32a) hydrochloride is 8.3 μM in HEK293T/PAD2 cells, the enhanced potency of PAD2-IN-1 overcomes its relatively poor ability to enter cells[1].
PAD2-IN-1 (compound 32a; 1-25 μM) hydrochloride treatment strongly inhibits histone H3 citrullination with an EC50of 2.7 μM in HEK293T/PAD2 cells[1].