SIRT2-IN-9

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SIRT2-IN-9

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

522650-91-5

包装与价格：

包装	价格(元)
10mg	电议
25mg	电议
50mg	电议
100mg	电议

产品介绍

SIRT2-IN-9 (compound 12) 是 SRIT2 的选择性抑制剂，IC50 值为 1.3 μM。SIRT2-IN-9 抑制 MCF-7 乳腺癌细胞的增殖活性。SIRT2-IN-9 可用于癌症的研究。

Cas No.

522650-91-5

分子式

C₂₁H₂₂N₆OS₂

分子量

438.57

溶解度

DMSO : 4.46 mg/mL (10.17 mM; ultrasonic and warming and heat to 70°C)

储存条件

4°C, protect from light

General tips

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

SIRT2-IN-9 (compound 12) is a selective inhibitor ofSRIT2with anIC₅₀value of 1.3 μM. SIRT2-IN-9 inhibits proliferative activity of MCF-7 breast cancer cells. SIRT2-IN-9 can be used for the research of cancer^[1].

SIRT2-IN-9 (1-100 μM; 15 min) dose-dependently inhibits SRIT2 with an IC₅₀value of 1.3 μM, and inhibits SRIT1 and SRIT3 with IC₅₀s ＞300 μM^[1].
SIRT2-IN-9 (0-50 μM; 72 h) affects cell viability of MCF-7 cells^[1].
SIRT2-IN-9 (0-50 μM; 6 h) affects acetylation of α-tubulin protein^[1].

Cell Proliferation Assay^[1]

Cell Line:	MCF-7 breast cancer cell line
Concentration:	0-50 μM
Incubation Time:	72 hours
Result:	Dose-dependently inhibited cell proliferation of MCF-7 breast cancer cells.

Western Blot Analysis^[1]

Cell Line:	MCF-7 breast cancer cell line
Concentration:	6.25, 12.5, 25 and 50 μM
Incubation Time:	6 hours
Result:	Dose-dependently increased acetylation of α-tubulin protein.