CAS NO: | 2565705-03-3 |
包装 | 价格(元) |
10mg | 电议 |
25mg | 电议 |
Cas No. | 2565705-03-3 | ||||||||
分子式 | C23H19ClF2N8O5S | ||||||||
分子量 | 592.96 | ||||||||
溶解度 | DMSO : 250 mg/mL (421.61 mM; Need ultrasonic) | ||||||||
储存条件 | Store at -20°C | ||||||||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. | ||||||||
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request | ||||||||
产品描述 | Dot1L-IN-5 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with anIC50 SPA DOT1Lof 0.17 nM[1]. Dot1L-IN-5 (Compound 11) is tested in cellular assays to assess the ability to inhibit the dimethylation of H3K79 in HeLa cells (ED50 H3K79me2 Elisa=2.9 nM) and HOXA9 gene expression in Molm-13 cells (ED50 HOXA9 RGA=30 nM)[1]. Dot1L-IN-5 (Compound 11; subcutaneous injection; at 75 mg/kg once daily for 20 days) does not lead to tumor growth inhibition in NOD-SCID mice. Dot1L-IN-5 (subcutaneous injection; at 75 mg/kg twice daily for 20 days) leads 73% growth inhibition[1].
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