您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > NN-390
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
NN-390
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NN-390图片
CAS NO:2490284-25-6
包装与价格:
包装价格(元)
500 µg电议
1mg电议
5mg电议

产品介绍
NN-390 是一种有效的选择性 HDAC6 抑制剂,IC50 为 9.8 nM。 NN-390 穿透血脑屏障 (BBB)。 NN-390 在转移性 3 MB 组(髓母细胞瘤)中显示出研究潜力。
Cas No.2490284-25-6
Canonical SMILESO=C(C1=CC=C(CN(S(=O)(C2=CC(F)=C(C(F)=C2F)F)=O)C(C)C)C=C1)NO
分子式C17H16F4N2O4S
分子量420.4
溶解度DMSO: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NN-390 is an inhibitor of histone deacetylase 6 (HDAC6; IC50= 9.8 nM).1It is selective for HDAC6 over HDAC3, HDAC8, and HDAC11 (IC50s = >1,000 nM for all). NN-390 is cytotoxic to MV4-11 leukemia, MM.1S multiple myeloma, and HD-MB03 medulloblastoma cells (IC50s = 1.19, 1.38, and 0.13 µM, respectively).

1.Nawar, N., Bukhari, S., Adile, A.A., et al.Discovery of HDAC6-selective inhibitor NN-390 with in vitro efficacy in group 3 medulloblastomaJ. Med. Chem.65(4)3193-3217(2022)