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PROTAC EZH2 Degrader-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PROTAC EZH2 Degrader-1图片
CAS NO:2641601-67-2
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
PROTAC EZH2 Degrader-1 (Compound 150d) 是一种有效的 PROTAC EZH2 降解剂,对 EZH2 甲基转移酶活性具有抑制作用,IC50 为 2.7 nM。EZH2 在许多肿瘤发生和发展过程中发挥着重要作用。
Cas No.2641601-67-2
分子式C54H67N7O8
分子量942.15
溶解度DMSO : 160 mg/mL (169.82 mM; Need ultrasonic)
储存条件-20°C, away from moisture
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PROTAC EZH2 Degrader-1 (Compound 150d), a potent PROTAC EZH2 Degrader, exerts inhibitory effect on EZH2 methyltransferase activity with the IC50 of 2.7 nM. EZH2 plays an important role in many tumorigenesis and development processes[1].

[1]. Juan Xia, et al. Targeting Enhancer of Zeste Homolog 2 for the Treatment of Hematological Malignancies and Solid Tumors: Candidate Structure-Activity Relationships Insights and Evolution Prospects. J Med Chem. 2022 May 26;65(10):7016-7043.