| CAS NO: | 1801530-11-9 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Cas No. | 1801530-11-9 |
| Canonical SMILES | O=C1N(C2=CC(C(CN3C=NC=C3)=O)=CC=C2OC(C)C)C(CN4CCN(C(COC5=CC=C(Cl)C=C5)=O)CC4)=NC6=CC=CC=C61 |
| 分子式 | C35H35ClN6O5 |
| 分子量 | 655.1 |
| 溶解度 | DMF: 10mg/mL,DMSO: 1mg/mL,DMSO:PBS (pH 7.2) (1:2): 0.25mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Imidazole ketone erastin is an inducer of ferroptosis.1It inhibits glutamate release in human CCF-STTG1 astrocytoma cells (IC50= 30 nM), indicating inhibition of the system xc-cystine/glutamate transporter.2Imidazole ketone erastin increases production of lipid reactive oxygen species (ROS) in SUDHL6 diffuse large B cell lymphoma (DLBCL) cells in a concentration-dependent manner, as well as reduces glutathione (GSH) levels in these cells (IC50= 34 nM).1It inhibits the growth of HT-1080 fibrosarcoma cells (GI50= 310 nM) as well as HRASG12V-overexpressing BJeLR cells (IC50= 3 nM).2Imidazole ketone erastin (23 and 40 mg/kg) reduces tumor growth in an SUDHL6 mouse xenograft model.1 1.Zhang, Y., Tan, H., Daniels, J.D., et al.Imidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma modelCell Chem. Biol.26(5)623-633(2019) 2.Larraufie, M.-H., Yang, W.S., Jiang, E., et al.Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubilityBioorg. Med. Chem. Lett.25(21)4787-4792(2015) |
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