| CAS NO: | 4921-49-7 |
| 包装 | 价格(元) |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Cas No. | 4921-49-7 |
| 别名 | 茶苯海明相关物质E |
| Canonical SMILES | O=C1C2=C(N(C)C(N1C)=O)N=C(N2C)Cl |
| 分子式 | C8H9ClN4O2 |
| 分子量 | 228.6 |
| 溶解度 | Chloroform: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 8-chloro Caffeine is a derivative of the methylxanthine alkaloid caffeine . It binds to adenosine receptors (apparent Ki= 30 µM).18-chloro Caffeine (250 µM) potentiates UV-induced chromosomal aberrations in Cl-I Chinese hamster embryonic lung cells.2It has also been used in the synthesis of mixed lineage kinase domain-like protein (MLKL) inhibitors with necroptosis-inhibiting activity.3 1.Bruns, R.F.Adenosine antagonism by purines, pteridines and benzopteridines in human fibroblastsBiochem. Pharmacol.30(4)325-333(1981) 2.Nilsson, K., and Lehmann, A.R.The effect of methylated oxypurines on the size of newly-synthesized DNA and on the production of chromosome aberrations after UV irradiation in Chinese hamster cellsMutat. Res.30(2)255-266(1975) 3.Yan, B., Liu, L., Huang, S., et al.Discovery of a new class of highly potent necroptosis inhibitors targeting the mixed lineage kinase domain-like proteinChem. Commun. (Camb.)53(26)3637-3640(2017) |
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