您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > T-1095
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
T-1095
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
T-1095图片
CAS NO:209746-59-8
包装与价格：
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
T-1095 是一种选择性和口服活性的 Na+-葡萄糖协同转运蛋白 (SGLT) 抑制剂，对人 SGLT1 和 SGLT2 的 IC50 分别为 22.8 μM 和 2.3 μM。
Cas No.209746-59-8
Canonical SMILESO=C(CCC1=CC=C(OC=C2)C2=C1)C(C(O)=CC(C)=C3)=C3O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)COC(OC)=O
分子式C26H28O11
分子量516.5
溶解度DMF: 5 mg/ml,DMSO: 2 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): insol
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

T-1095 is an inhibitor of sodium-glucose cotransporter 1 (SGLT1) and SGLT2 (IC50s = 22.8 and 2.3 µM, respectively).1Dietary administration of T-1095 (0.01% w/w) reduces blood glucose and HbA1c levels in a rat model of diabetes induced by streptozotocin . It suppresses the development of hyperglycemia and hypertriglyceridemia and reduces HbA1c levels in the KKAγ mouse model of type 2 diabetes. T-1095 exacerbates post-infarction cardiac dysfunction in a rat model of left anterior descending coronary artery ligation-induced myocardial infarction.2

1.Oku, A., Ueta, K., Ishihara, T., et al.T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetesDiabetes48(9)1794-1800(1999) 2.Bruno, J.G., Herman, T.S., Cano, V.L., et al.Selective cytotoxicity of 3-amino-L-tyrosine correlates with peroxidase activityIn Vitro Cell. Dev. Biol. Anim.35(7)376-382(1999)