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N-desmethyl Regorafenib N-oxide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
N-desmethyl Regorafenib N-oxide图片
CAS NO:835621-12-0
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
An active metabolite of regorafenib
Cas No.835621-12-0
别名瑞戈非尼杂质14
Canonical SMILESO=C(C1=CC(OC2=CC(F)=C(NC(NC3=CC(C(F)(F)F)=C(Cl)C=C3)=O)C=C2)=CC=[N]1=O)N
分子式C20H13ClF4N4O4
分子量484.8
溶解度DMSO: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

N-desmethyl Regorafenib N-oxide is an active metabolite of the multi-kinase inhibitor regorafenib .1It is formed from regorafenib by the cytochrome P450 (CYP) isoform CYP3A4. N-desmethyl Regorafenib N-oxide inhibits VEGFR2, Tie2, c-Kit, and B-RAFin vitro, as well as inhibits tumor growth in HT-29 and MDA-MB-231 mouse xenograft models when administered at a dose of 1 mg/kg.2

1.Li, Y.-H., Lin, Q.-M., Pang, N.-H., et al.Functional characterization of 27 CYP3A4 protein variants to metabolize regorafenib in vitroBasic Clin. Pharmacol. Toxicol.125(4)337-344(2019) 2.Zopf, D., Heinig, R., Thierauch, K.-H., et al.Abstract 1666: Regorafenib (BAY 73-4506): Preclinical pharmacology and clinical identification and quantification of its major metabolitesCancer. Res.70(8 Suppl.)(2010)