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RAS/RAS-RAF-IN-1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
RAS/RAS-RAF-IN-1图片
CAS NO:2447039-81-6
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
RAS/RAS-RAF-IN-1 是有效的 RAS 和 RAS-RAF 抑制剂。RAS/RAS-RAF-IN-1 对于亲环蛋白 A (CYPA) 结合亲和力的 KD 值为 5.0 μM-15 μM。RAS/RAS-RAF-IN-1 具有抗肿瘤活性。
Cas No.2447039-81-6
分子式C45H57N7O7
分子量807.98
储存条件4°C, protect from light, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

RAS/RAS-RAF-IN-1 is a potent RAS and RAS-RAF inhibitor. RAS/RAS-RAF-IN-1 has a KD of 5.0 μμ-15 μμ for cyclophilin A (CYPA) binding affinity. RAS/RAS-RAF-IN-1 has antitumor activity[1].

RAS/RAS-RAF-IN-1 (compound 89; for 4 hours) has an EC50 of 0.5 μμ-5.0 μμ for BRAF-GTP-KRAS-G12C disruption and has an IC50 of 1.0 μμ-10 μμ for pERK inhibition in H358 cells[1].

[1]. Meizhong Jin, et al. Compounds that participate in cooperative binding and uses thereof. WO2020132597A1.