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Tovetumab
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1243266-04-7
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Tovetumab (MEDI-575) 是一种抗 PDGFRα 单克隆抗体,可选择性的阻断 PDGFRα 信号转导。Tovetumab 可用于胶质母细胞瘤和非小细胞肺癌 (NSCLC) 的研究。
Cas No.1243266-04-7
别名MEDI-575
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tovetumab (MEDI-575) is an anti-PDGFRαmonoclonal antibody that selectively blocks the PDGFRα signal transduction. Tovetumab can be used in the research of glioblastoma and non-small cell lung cancer (NSCLC)[1][2].

Tovetumab (10-100 nM, 1-2 h) binds to PDGFRα on H1703 cells (determined by Alexa647-labeled tovetumab)[1].
Tovetumab (0.001-10 nM, 10 min) inhibits ligand-induced phosphorylation of human PDGFRα in MG-63 cells[2].
Tovetumab (0.001-100 nM, 72 h ) inhibits Ligand-induced proliferation of cancer-associated fibroblasts (CAFs)[2].

Tovetumab (0.6-60 mg/kg, i.v.) blocks the PDGFRα-mediated elimination of PDGF-AA, leading to an increase in circulating PDGF-AA level in Cynomolgus monkeys[1].
Tovetumab (10 mg/kg, i.p., twice a week) inhibits tumor growth in U118 glioma xenografts[2].

Animal Model:Cynomolgus monkey[1]
Dosage:0.6, 6.0, and 60 mg/kg
Administration:Intravenous injection (i.v.)
Result:Induced > 100- fold increases in circulating concentrations of PDGF-AA.
Animal Model:U118 glioma xenografts (CB17 SCID)[2]
Dosage:10 mg/kg
Administration:Intraperitoneal injection (i.p.), twice per week.
Result:Produced 101% inhibition of tumor growth.