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Zilovertamab
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
包装:5mg
市场价:11250元

产品介绍
Zilovertamab (UC-961) 是一种人源化抗 ROR1 单克隆抗体,可阻断 Wnt5a 诱导的 ROR1 信号通路。
别名UC-961; Cirmtuzumab
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Zilovertamab (UC-961) is a humanised monoclonal antibody againstROR1that blocks Wnt5a-induced ROR1 signalling[1].

Zilovertamab (25 and 50 µg/mL; 72 h) inhibits high-grade serous ovarian cancer (HGSOC) cell proliferation[1].
Zilovertamab (50 µg/mL; 72 h) down-regulates ROR1 expression levels in CaOV3 at the transcriptional level[1].

Cell Proliferation Assay[1]

Cell Line:CaOV3, CaOV3CisR, PEO1, and PEO4 cells
Concentration:25 and 50 µg/mL
Incubation Time:72 hours
Result:Reduced the proliferation of CaOV3, CaOV3CisR and PEO1.

Western Blot Analysis[1]

Cell Line:CaOV3, CaOV3CisR, PEO1, and PEO4 cells
Concentration:50 µg/mL
Incubation Time:72 hours
Result:Down-regulated ROR1 expression levels in CaOV3 at the transcriptional level.