您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > c-Kit-IN-5-1
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
c-Kit-IN-5-1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
c-Kit-IN-5-1图片
CAS NO:1003311-62-3
包装与价格：
包装价格(元)
10mg电议
25mg电议

产品介绍
c-Kit-IN-5 是一种有效的 c-Kit 抑制剂，在激酶试验和细胞试验中的 IC50 值分别为 22 nM 和 16 nM。c-Kit-IN-5 对 c-Kit 的选择性比 KDR、p38、Lck 和 Src 高 200 倍以上。c-Kit-IN-5 还表现出理想的药代动力学特性。
Cas No.1003311-62-3
分子式C23H17N5O2
分子量395.41
溶解度DMSO : 25 mg/mL (63.23 mM; ultrasonic and warming and heat to 80°C)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

c-Kit-IN-5 is potent inhibitor ofc-Kit, withIC50s of 22 nM and 16 nM in kinase assay and cell assay, respectively. c-Kit-IN-5 shows more than 200-fold selectivity for c-Kit over KDR, p38, Lck, and Src. c-Kit-IN-5 also exhibits desirable pharmacokinetic properties[1].

c-Kit-IN-5 (compound 25) shows more than 200-fold selectivity against KDR, p38, Lck, and Src (IC50=>5.0, 40, 7.8 , and >5.0 μM, respectively)[1].

c-Kit-IN-5 (compound 25) (1 mg/kg; i.v.) exhibits CL (0.46 L/h/kg) and Vdss(1.59 L/kg) in rats[1].
c-Kit-IN-5 (10 mg/kg; p.o.) exhibits AUC0-t(9860 ng•h/mL) Cmax(1230 ng/mL), T1/2(2.6 h), and F (39%) in rats[1].