| CAS NO: | 2767422-72-8 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 2767422-72-8 |
| 分子式 | C24H29N5O2 |
| 分子量 | 419.52 |
| 溶解度 | DMSO : 50 mg/mL (119.18 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 80°C) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | HS-276 is an orally active, potent and highly selectiveTAK1inhibitor, with aKiof 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, withIC50values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 can be used for rheumatoid arthritis (RA) research[1]. HS-276 reduces expression of TNF, IL-6, and IL-1β in a dose-dependent manner, with IC50values of 138, 201, and 234 nM, respectively[1]. HS-276 (CIA mouse model of inflammatory arthritis, 50 mg/kg, IP, daily for 6 days) reduces inflammation, pannus, cartilage damage (CD), bone resorption (BR), and periosteal bone formation (PBF) histological manifestations[1]. |
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