| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 100mg | 电议 |
| 别名 | F-ara-ATP trisodium |
| 分子式 | C10H12FN5Na3O13P3 |
| 分子量 | 591.12 |
| 溶解度 | H2O : 250 mg/mL (422.93 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | IC50: 2.3 ± 0.3 μM (DNA primase); Ki: 6.1 ± 0.3 μM (DNA primase)[1] Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite ofFludarabine, is a potent, noncompetitive and specific inhibitor ofDNA primase, with anIC50of 2.3 μM and aKiof 6.1 μM. Fludarabine triphosphate trisodium inhibitsDNA synthesisby blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellularapoptosis[1][2]. Fludarabine triphosphate trisodium is a more potent inhibitor of the polydeoxythymidylate primase activity than of the DNA polymerase α/δ activities present in the supernatants of CCRF-CEM cells[1]. |
m.cnreagent.com