β-Amyrone

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β-Amyrone

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	638-97-1
包装:	5mg
市场价:	7560元

产品介绍

β-Amyrone (β-Amyron) 是一种三萜类化合物，通过抑制 COX-2 的表达而发挥抗炎活性。β-Amyrone 具有抗真菌活性，及针对 Chikungunya 病毒的抗病毒活性。β-Amyrone 还可抑制 α-葡萄糖苷酶 (α-glucosidase ) 和乙酰胆碱酯酶 (AChE) 的活性。β-Amyrone 可用于炎症，感染，肥胖等疾病的研究。

Cas No.

638-97-1

别名

β-Amyron

分子式

C₃₀H₄₈O

分子量

424.7

储存条件

4°C, protect from light

General tips

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression ofCOX-2. β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibitsα-glucosidaseand acetylcholinesterase (AChE) activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity^[1]^[2]^[3]^[4].

β-Amyrone (1.25-10 μg/mL, 24 h) inhibits on NO^?production in LPS-stimulated J774 cells, with an IC₅₀value of 4.61 μg/mL, and has no obvious effect on cell viability^[1].
β-Amyrone (10 μg/mL, 24 h) inhibits IL-6, IL-10 levels, and COX-2 expression in LPS-stimulated J774 cells^[1].
β-Amyrone (0-235 μM, 7days) has antiviral activity in Vero cells against Chikungunya virus (CHIKV), with EC₅₀value of 86 uM^[2].
β-Amyrone inhibits α-glucosidase, acetylcholinesterase (AChE) and fungal activity with IC₅₀values of 25 μM, 23 μM and 8 μg/mL, respectively^[4].

Western Blot Analysis^[1]

Cell Line:	LPS (1 μg/mL)-stimulated J774 cells
Concentration:	2.5, 5, 10 μg/mL
Incubation Time:	24 h
Result:	Inhibited COX-2 expression in a concentration-dependent manner (approximately 90% reduction at 5 or 10 μg/ mL).

β-Amyrone (local administration on ear, 0.1-0.6 mg/kg, a single dose) inhibits ear edema formation in phenol-induced edema mice^[1].

Animal Model:	Ear phenol-induced edema in Balb C mice^[1]
Dosage:	0.1, 0.3, 0.6 mg/kg, a single dose
Administration:	Local administration (20 ??L solution) on ear
Result:	Inhibited ear edema formation in a dose-related manner (47% inhibition at the dose of 0.6mg/kg).