Dynole 2-24 是一种基于吲哚的 dynamin GTPase 抑制剂 (对 dynamin I的IC50=0.56 μM)。Dynole 2-24 无毒，在体外和细胞内显示出增强的抗动力蛋白I和II的效力 (IC??(CME)=1.9 μM)。Dynole 2-24 对 dynamin I的选择性为4.4倍。Dynole 2-24在网格蛋白介导的内吞作用的细胞抑制剂中具有活性。CME: Clathrin mediated endocytosis
| Cas No. | 1416313-72-8 |
| 分子式 | C24H41N3 |
| 分子量 | 371.6 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Dynole 2-24 is an indole-baseddynamin GTPaseinhibitor (IC50=0.56 μM for dynamin I). Dynole 2-24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC??(CME)=1.9 μM). Dynole 2-24 also shows 4.4-fold selectivity for dynamin I. Dynole 2-24 is active in-cell inhibitor of clathrin-mediated endocytosis[1]. CME: Clathrin mediated endocytosis |
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