包装 | 价格(元) |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
分子式 | C33H36FN7O3S.1/2H2O |
分子量 | 638.77 |
溶解度 | DMSO : 100 mg/mL (156.55 mM; Need ultrasonic) |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | AZ13705339 hemihydrate is a highly potent and selectivePAK1inhibitor withIC50s of 0.33 nM and 59 nM for PAK1 and pPAK1, respectively. AZ13705339 hemihydrate has binding affinities to PAK1 and PAK2, withKds of 0.28 nM and 0.32 nM, respectively. AZ13705339 hemihydrate can be used in the research of cancers[1]. AZ13705339 (1 μM) hemihydrate inhibits αIgM-controlled adhesion and not PMA-induced adhesion in Namalwa cells[2]. AZ13705339 hemihydrate (100 mg/kg, P.O.) has moderate clearance and oral Cmaxof 7.7 μM in rats[1]. |