CAS NO: | 2243882-74-6 |
包装 | 价格(元) |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
Cas No. | 2243882-74-6 |
分子式 | C26H28Cl2N6O |
分子量 | 511.45 |
溶解度 | DMSO : 125 mg/mL (244.40 mM; Need ultrasonic) |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | WEE1-IN-5 is a potentWEE1inhibitor with anIC50value of 0.8 nM. WEE1-IN-5 inhibits phospho-CDC2. WEE1-IN-5 abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. WEE1-IN-5 can be used for researching anticancer[1]. WEE1-IN-5 exhibits an EC50of 188 nM in pCDC2 and an IC50shift for CYP3A4/5[1]. WEE1-IN-5 (5mg/kg for PO; 1 mg/kg for IV; single dosage) exhibits a CL of 14 mL/min/kg, an AUCint1324 h.ng/mL and bioavailability of 35% in SD rats[1]. |