CAM833 是一种有效的抑制 BRCA2 和 RAD51 之间相互作用的正位抑制剂，对 ChimRAD51 蛋白的 Kd 为 366 nM。 CAM833 也抑制 RAD51 的寡聚。
| Cas No. | 2758364-02-0 |
| 分子式 | C26H26ClFN4O5 |
| 分子量 | 528.96 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | CAM833 is a potent orthosteric inhibitor of the interaction betweenBRCA2andRAD51with aKdof 366 nM against the ChimRAD51 protein. CAM833 also inhibits RAD51 oligomerization[1]. CAM833 (3.125-50 μM; 24 h) causes a concentration-dependent decrease in RAD51 foci and subsequent increase in DNA damage[1].
CAM833 (25 μM) inhibits RAD51 molecular clustering at DNA damage sites[1].
CAM833 (0-50 μM) inhibits DNA repair by homologous recombination[1].
CAM833 (20 μM; 0-72 h) potentiates radiation-induced cell-cycle arrest and increases apoptosis over time[1].
CAM833 (10 μM) causes a dose-dependent growth inhibition that is enhanced when combined with ionizing radiation[1].
CAM833 (20 μM; 96 h) potentiates the growth suppressive effect of PARP1 inhibition in BRCA2 wild-type cells[1]. Cell Cycle Analysis[1] | Cell Line: | HCT116 cells | | Concentration: | 20 μM | | Incubation Time: | 0-72 h | | Result: | In the control the percentage of cells in the apoptotic subG1 fraction remains below 5% throughout, in the compound-treated cells this rises progressively to peak at 15% at 48 hours. |
|
m.cnreagent.com