您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > Hexa-D-Arginine(trifluoroacetate salt)
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Hexa-D-Arginine(trifluoroacetate salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Hexa-D-Arginine(trifluoroacetate salt)图片
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
A furin inhibitor
Canonical SMILESN=C(N)NCCC[C@@H](N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@@H](C(N)=O)CCCNC(N)=N)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
分子式C36H75N25O6 • XCF3COOH
分子量954.1
溶解度Acetonitrile/Water (80:20): 1 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Hexa-D-arginine is an inhibitor of the proprotein convertase furin (Ki= 100 nM).1It also inhibits West Nile virus nonstructural protein 3 (NS3) protease (Ki= 478 nM). Hexa-D-arginine (1 µg/ml) reduces the proliferation, invasion, and migration of SW 1990 and PaTu 8988 pancreatic cancer cells, as well as decreases the levels of N-cadherin and vimentin and increases E-cadherin levels, markers of the epithelial-to-mesenchymal transition (EMT), in the same cells.2It improves survival in a rat model of anthrax toxemia induced by the anthrax toxins protective antigen and lethal factor.3

1.Shiryaev, S.A., Ratnikov, B.I., Chekanov, A.V., et al.Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinaseBiochem. J.393(Pt 2)503-511(2006) 2.Zhou, M., Zhang, Y., Wei, H., et al.Furin inhibitor D6R suppresses epithelial?mesenchymal transition in SW1990 and PaTu8988 cells via the Hippo?YAP signaling pathwayOncol. Lett.15(3)3192-3196(2018) 3.Sarac, M.S., Peinado, J.R., Leppla, S.H., et al.Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivoInfect. Immun.72(1)605-605(2004)