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Davunetide(acetate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Davunetide(acetate)图片
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
A neuroprotective ADNP-derived peptide
Canonical SMILESO=C([C@H]1N(CCC1)C([C@H](C)NC([C@@H](N)CC(N)=O)=O)=O)N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N2[C@@H](CCC2)C(N[C@H](C(O)=O)CCC(N)=O)=O)=O)=O)=O.CC(O)=O
分子式C36H60N10O12 • XC2H4O2
分子量824.9
溶解度DMF: 1 mg/ml,DMSO: 1 mg/ml,Ethanol: insol,PBS (pH 7.2): 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Davunetide is a neuroprotective peptide derived from activity-dependent neuroprotective protein (ADNP).1It promotes tubulin assembly in a cell-free assay when used at a concentration of 1 fM.2Davunetide (1 fM) protects against cytotoxicity induced by tetrodotoxin , a peptide derived from amyloid-β (Aβ), or zinc in isolated neonatal cerebral cortical cells.1,2Intravitreal administration of davunetide (4 µl of a 100 µg/ml solution) inhibits increases in cleaved caspase-3 and decreases in Bcl-2 levels in retina isolated from streptozotocin-induced diabetic rats.3It improves survival in a superoxide dismutase 1 mutant (SOD1G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS) when administered at 10 µg/animal.4Davunetide prevents decreases in brain choline acetyltransferase (ChAT) activity and prevents memory deficits in the Morris water maze in anApoe-/-mouse model of neurodegeneration.1

1.Bassan, M., Zamostiano, R., Davidson, A., et al.Complete sequence of a novel protein containing a femtomolar-activity-dependent neuroprotective peptideJ. Neurochem.72(3)1283-1293(1999) 2.Divinski, I., Mittelman, L., and Gozes, I.A femtomolar acting octapeptide interacts with tubulin and protects astrocytes against zinc intoxicationJ. Biol. Chem.279(27)28531-28538(2004) 3.Scuderi, S., D’Amico, A.G., Castorina, A., et al.Davunetide (NAP) protects the retina against early diabetic injury by reducing apoptotic deathJ. Mol. Neurosci.54(3)395-404(2014) 4.Jouroukhin, Y., Ostritsky, R., Assaf, Y., et al.NAP (davunetide) modifies disease progression in a mouse model of severe neurodegeneration: Protection against impairments in axonal transportNeurobiol. Dis.5679-94(2013)