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Chroman 1(hydrochloride hydrate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Chroman 1(hydrochloride hydrate)图片
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A ROCK2 inhibitor
Canonical SMILESCN(C)CCOC(C=C(C1=CNN=C1)C=C2)=C2NC([C@H]3CC4=CC(OC)=CC=C4OC3)=O.Cl.Cl.O
分子式C24H28N4O4·2HCl [XH2O]
分子量527.4
溶解度DMSO: 100 mM,Water: 5 mM
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Chroman 1 is an inhibitor of Rho-associated kinase 2 (ROCK2; IC50=<1 nm).1It is selective for ROCK2 over protein kinase A (PKA) and Cdc42-binding kinase (MRCKα; IC50s = 1,740 and 127 nM, respectively). Chroman 1 inhibits phosphorylation of myosin light chain (MLC) in a cell-based assay (IC50=<4 nM).

1.Chen, Y.T., Vojkovsky, T., Fang, X., et al.Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitorsMed. Chem. Commun.2(1)73-75(2011)