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Imatinib D4
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Imatinib D4图片
CAS NO:1134803-16-9
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
ImatinibD4(STI571D4)是Imatinib(STI571)的氘代物。Imatinib是一种口服生物可用的酪氨酸激酶抑制剂，可选择性抑制BCR/ABL，v-Abl，PDGFR，c-kit激酶活性。
Cas No.1134803-16-9
别名[2H4]-伊马替尼,STI571 D4; CGP-57148B D4
Canonical SMILESO=C(NC1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1)C4=C([2H])C([2H])=C(CN5CCN(C)CC5)C([2H])=C4[2H]
分子式C29H27D4N7O
分子量497.63
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Imatinib D4 (STI571 D4) is a deuterium labeled Imatinib (STI571). Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity[1][2].

[1]. Heinrich MC, et al. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood. 2000 Aug 1;96(3):925-32. [2]. Guida T, et al. Sorafenib inhibits imatinib-resistant KIT and platelet-derived growth factor receptor beta gatekeeper mutants. Clin Cancer Res. 2007 Jun 1;13(11):3363-9. [3]. Coleman CM, et al, Frieman MB. Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion. J Virol. 2016;90(19):8924‐8933. Published 2016 Sep 12.