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ESI-08
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ESI-08图片
CAS NO:301177-43-5
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
ESI-08 是一种有效的选择性 EPAC 拮抗剂,可以完全抑制 EPAC1 和 EPAC2 (IC50 为 8.4 μM) 的活性。ESI-08 选择性阻断 cAMP 诱导的 EPAC 激活,但不抑制 cAMP 介导的 PKA 激活。
Cas No.301177-43-5
分子式C20H23N3OS
分子量353.48
溶解度DMSO : 100 mg/mL (282.90 mM; ultrasonic and warming and heat to 60°C)
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IC50: 8.4 μM (EPAC2)[1]
EPAC1[1]

ESI-08 is a potent and selectiveEPACantagonist, which can completely inhibit bothEPAC1andEPAC2(IC50of 8.4 μM) activity. ESI-08 selectively blocks cAMP-inducedEPACactivation, but does not inhibit cAMP-mediated PKA activation[1].

Exchange proteins directly activated by cAMP (EPAC) are a family of guanine nucleotide exchange factors that regulate a wide variety of intracellular processes in response to second messenger cAMP. ESI-08 at 25 μM has been found not to alter cAMP-induced type I and II PKA holoenzymes activation while H89, a selective PKA inhibitor, blocked the type I or II PKA activities completely[1].