CAS NO: | 301177-43-5 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
Cas No. | 301177-43-5 |
分子式 | C20H23N3OS |
分子量 | 353.48 |
溶解度 | DMSO : 100 mg/mL (282.90 mM; ultrasonic and warming and heat to 60°C) |
储存条件 | 4°C, protect from light |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | IC50: 8.4 μM (EPAC2)[1] ESI-08 is a potent and selectiveEPACantagonist, which can completely inhibit bothEPAC1andEPAC2(IC50of 8.4 μM) activity. ESI-08 selectively blocks cAMP-inducedEPACactivation, but does not inhibit cAMP-mediated PKA activation[1]. Exchange proteins directly activated by cAMP (EPAC) are a family of guanine nucleotide exchange factors that regulate a wide variety of intracellular processes in response to second messenger cAMP. ESI-08 at 25 μM has been found not to alter cAMP-induced type I and II PKA holoenzymes activation while H89, a selective PKA inhibitor, blocked the type I or II PKA activities completely[1]. |