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SAE-14
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SAE-14图片
CAS NO:1241280-25-0
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议

产品介绍
SAE-14 (compound SAE-14) 是一种有效、特异的 GPR183 拮抗剂,IC50值为 28.5 nM,可抑制 HL-60 细胞中 7α, 25-OHC 诱导的钙信号转导, IC50 值低于 50 nM。SAE-14 可逆转小鼠的异位性疼痛。
Cas No.1241280-25-0
别名GPR183 antagonist-1
分子式C19H19F3N2O2
分子量364.36
溶解度DMSO : 100 mg/mL (274.45 mM; ultrasonic and warming and heat to 60°C)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IC50: 28.5 nM (GPR183)[1]

SAE-14 (compound SAE-14) is a potent, specificGPR183antagonist with anIC50value of 28.5 nM, can antagonize 7α, 25-OHC-induced calcium mobilization withIC50value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice[1].

SAE-14 (compound SAE-14) can able to antagonize 7α, 25-OHC-induced calcium mobilization with an IC50value below 50 nM[1].

Cell Viability Assay[1]

Cell Line:The human leukemia (HL)-60 cells
Concentration:5×of the antagonist
Incubation Time:15 min
Result:Had GPR183-specific (IC50: 28.5nM) and abolished 7a, 25-OHC-induced calcium mobilization in the HL-60 cells.

SAE-14 (compound SAE-14) (i.th.; 2.9 µM; once) can reverse nerve injury-induced allodynia in mice[1].

Animal Model:Male and female ICR mice[1]
Dosage:2.9 µM
Administration:intrathecal (i.th.) injections; 2.9 µM; once
Result:Reversed CCI-induced mechanical allodynia in a time-dependent manner.