TDI-011536

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TDI-011536

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	2687970-96-1
包装:	10mg
市场价:	8100元

产品介绍

TDI-011536 是一种有效的 Lats 激酶抑制剂，能中断 Hippo-Yap 的信号传导，并可启动受损心肌细胞的增殖。TDI-011536 可用于研究器官的保护和再生。

Cas No.

2687970-96-1

分子式

C₁₉H₁₆N₄O₂S

分子量

364.42

储存条件

Store at -20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

TDI-011536 is a potentLats kinaseinhibitor, interruptsHippo-Yapsignaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration^[1].

TDI-011536 (3 µM; 24 h) reduces Yap phosphorylation and (3 µM; 5 days) induces proliferation of MÜller glia in human retinal organoids^[1].

Cell Proliferation Assay^[1]

Cell Line:	human retinal organoids
Concentration:	3 µM
Incubation Time:	24 h, 5 days
Result:	Supressed Yap phosphorylation and promoted MÜller glia proliferation.

TDI-011536 (200 mg/kg; i.p.; once) provides over 4 h of Lats inhibition in the liver, heart, and skin and reduces the amount of pYap for at least 4 h after injection in all three organs^[1].
TDI-011536 (100 mg/kg; i.p.; once daily for 2 or 3 days) shows proliferative effect on cardiomyocytes^[1].

Animal Model:	Living mice (immunoblot analysis of the heart, liver, and skin immediately after injection)^[1].
Dosage:	200 mg/kg
Administration:	Intraperitoneal injections; once.
Result:	Reduced the amount of pYap for at least 4 h after injection in all three organs and the levels returned to control values within a day.

Animal Model:	Male 8-week-old mice (cryolesion model)^[1].
Dosage:	100 mg/kg
Administration:	Intraperitoneal injections; once daily for 2 or 3 days.
Result:	Promoted cardiomyocytes proliferation.