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SK33
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SK33图片
CAS NO:1928724-23-5
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
SK33,肌醇类似物,是一种有效的组织选择性抗雄激素药物。SK33 降低雄激素受体 (AR) 的转录活性。
Cas No.1928724-23-5
分子式C20H13F9N2O3
分子量500.31
溶解度DMSO : 100 mg/mL (199.88 mM; Need ultrasonic)
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity[1].

In LNCaPAR+ cells, SK33, demonstrates a significantly potent activity with IC50=0.2 μM. SK33 decreases cells entering S-phase in LNCaP cells. Treatment of LNCaP/BicR cells with increasing concentrations of SK33 for 96 hours results in a dose-dependent response and an inhibition of cell growth, with IC50 of approximately 5 μM for SK33[1].

SK33 (50 mg/kg; s.c.; 24 hours) inhibits AR transcriptional activity[1].

[1]. Dart DA, et al. Novel Trifluoromethylated Enobosarm Analogues with Potent Antiandrogenic Activity In Vitro and Tissue Selectivity In Vivo.Mol Cancer Ther. 2018 Sep;17(9):1846-1858.