ODN 2216

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ODN 2216

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	332437-00-0
包装:	5mg
市场价:	10350元

产品介绍

ODN 2216 是一种 TLR9 (toll 样受体 9) 配体或激动剂。ODN 2216 诱导大量的 IFN-α 和 IFN-β。ODN 2216 通过 pDC (浆细胞样 DC) 诱导 IFN-α，并通过 DC (树突状细胞)产生 IL-12 (p40)。ODN 2216 刺激外周血单核细胞 (PBMC) 产生 IFN-γ，这是间接的和由 IFN-α/β 介导的。ODN 2216 可以激活 NK 细胞，促进 IFN-γ 产生 TCR 触发的 CD4+ T 细胞。

Cas No.

332437-00-0

储存条件

Store at -20°C, away from moisture

General tips

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

ODN?2216 is aTLR9(toll-like receptor 9) ligand or agonist. ODN?2216 induces high amounts ofIFN-αandIFN-β. ODN 2216 induces IFN-α by pDC (plasmacytoid DC) andIL-12 (p40)production by DC (dendritic cells). ODN 2216 stimulates IFN-γ production in peripheral blood mononuclear cells (PBMC), which is indirect and mediated by IFN-α/β. ODN 2216 can activate NK cells and promote IFN-γ production of TCR-triggered CD4⁺T cells^[1]^[2]^[3]^[4].

ODN 2216 (6 μg/mL, 9 days) drives Th1 development of naive CD4 T cells^[1].
ODN?2216 (2 μM, 15 h) significantly decreased apoptosis of thymic DC^[2].

Apoptosis Analysis^[2]

Cell Line:	Thymic DC, pDC
Concentration:	2 μM
Incubation Time:	15 h
Result:	Significantly decreased apoptosis of thymic DC (23.1 ± 0.9%), and naturally induced apoptosis of thymic pDC was not decreased (72.8 ± 2.9%).

ODN 2216 induces T-cell mediated antitumor immune response in murine vaccination models^[3]