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Canakinumab
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CAS NO:914613-48-2
包装:5mg
市场价:162000元

产品介绍
Canakinumab (ACZ885) 是一种重组的人抗 IL-1β 单克隆抗体。Canakinumab 显示出对人类和绒猴 IL-1β 的 IC50 值为分别为 43.6 和 40.8 pM。Canakinumab 的作用模式是基于对 IL-1β 信号的中和，从而抑制与自身免疫性疾病相关的炎症。
Cas No.914613-48-2
别名Ilaris; ACZ 885
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IC50: 43.6 pM (human IL-1β), 40.8 pM (marmoset IL-1β)[2]

Canakinumab (ACZ885) is a recombinant humananti-IL-1βmonoclonal antibody. Canakinumab showsIC50values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin[1][2].

Canakinumab (0-7 nM) dose dependently represses IL-6 production in marmoset peripheral blood mononuclear cells with IC50s of 43.6 and 40.8 pM for human and marmoset IL-1β[2].Canakinumab effectively competes with IL-1RI and IL-1RII for binding to IL-1b[2].