| CAS NO: | 1330266-05-1 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| Cas No. | 1330266-05-1 |
| 别名 | 磺胺邻二甲氧嘧啶-D4,Sulphadoxine-d4 |
| Canonical SMILES | O=S(NC1=NC=NC(OC)=C1OC)(C2=C([2H])C([2H])=C(C([2H])=C2[2H])N)=O |
| 分子式 | C12H10D4N4O4S |
| 分子量 | 314.4 |
| 溶解度 | Acetone: soluble,DMSO: soluble,Methanol: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Sulfadoxin-d4is intended for use as an internal standard for the quantification of sulfadoxin by GC- or LC-MS. Sulfadoxin is a sulfonamide antibiotic that inhibits dihydropteroate synthetase (DHPS), an enzyme involved in folic acid synthesis.1Sulfadoxin competes with 4-aminobenzoate (PABA), the native substrate of DHPS, and inhibits PABA incorporation into folic acid.2Folate is essential for purine and pyrimidine synthesis, therefore, sulfadoxin has antiproliferative activity in non-resistantP. falciparum.2,3Sulfadoxin inhibits growth ofP. falciparumin vitro, but potency varies between non-resistant (IC50= 4 ng/ml) and resistant strains (IC50= 3,970 ng/ml).3 1.Brooks, D.R., Wang, P., Read, M., et al.Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxineEur. J. Biochem.224(2)397-405(1994) 2.Hyde, J.E.Exploring the folate pathway in Plasmodium falciparumActa. Trop.94(3)191-206(2005) 3.Wang, P., Read, M., Sims, P.F.G., et al.Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization.Mol. Microbiol.23(5)979-986(1997) |
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