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(E)-3,4,5-Trimethoxycinnamic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(E)-3,4,5-Trimethoxycinnamic acid图片
CAS NO:20329-98-0
包装与价格:
包装价格(元)
50mg电议
100mg电议

产品介绍
(E)-3,4,5-Trimethoxycinnamic acid (TMCA) 是一种被多甲氧基取代的肉桂酸。(E)-3,4,5-Trimethoxycinnamic acid 是一种口服有效的 GABAA/BZ 受体激动剂。(E)-3,4,5-Trimethoxycinnamic acid 与 5-HT2C 和 5-HT1A 受体具有良好的结合亲和力,其 IC50 值分别为 2.5 和 7.6 μM。(E)-3,4,5-Trimethoxycinnamic acid 具有抗惊厥和镇静活性。(E)-3,4,5-Trimethoxycinnamic acid 可用于失眠、头痛、癫痫的研究。
Cas No.20329-98-0
别名TMCA
分子式C12H14O5
分子量238.24
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(E)-3,4,5-Trimethoxycinnamic acid (TMCA) is a cinnamic acid substituted by multi-methoxy groups. (E)-3,4,5-Trimethoxycinnamic acid is an orally active and potentGABAA/BZreceptor agonist. (E)-3,4,5-Trimethoxycinnamic exhibits favourable binding affinity to5-HT2Cand5-HT1Areceptor, withIC50values of 2.5 and 7.6 μM, respectively. (E)-3,4,5-Trimethoxycinnamic acid shows anticonvulsant and sedative activity. (E)-3,4,5-Trimethoxycinnamic acid can be used for the research of insomnia, headache and epilepsy[1][2][3].

(E)-3,4,5-Trimethoxycinnamic acid (10 μg/mL, 1 h) increases the expressions of GAD65and γ-subunit of GABAAreceptors in the cerebellar granule cells[3].
(E)-3,4,5-Trimethoxycinnamic acid (0-10 μg/mL, 1 h) shows a significant increase in Cl-influx[3].

Western Blot Analysis[3]

Cell Line:Primary cultured cerebellar granule cells
Concentration:10 μg/mL
Incubation Time:1 h
Result:Increased expression of GAD65(glutamic acid decarboxylase) and γ-subunit of GABAA receptors, but did not influence the amounts of a-, b-subunits in the GABAA receptors.

Cell Viability Assay[3]

Cell Line:Primary cultured cerebellar granule cells
Concentration:1, 3, 5, 10 μg/mL
Incubation Time:1 h
Result:Produced a significant increase in Cl-influx.

(E)-3,4,5-Trimethoxycinnamic acid (0-20 mg/kg, IP, once) shows anti-seizure effects[2].
(E)-3,4,5-Trimethoxycinnamic acid (0-10 mg/kg, Orally, once) enhances hypnotic effects in pentobarbital-treated mice[3].

Animal Model:Ault male KunMing-strain mice (18-20 g, maximal electroshock (MES) and pentylenetetrazol (PTZ) models)[2]
Dosage:5, 10 and 20 mg/kg; 10 mL/kg
Administration:IP, once
Result:Significantly decreased the incidence of MES-induced THE (tonic hindlimb extension) to 50% and 20% of the value of the vehicle controls at 10 and 20 mg/kg. Decreased the incidence of MES-induced THE to only 80% at 5 mg/kg. Significantly delayed the onset of myoclonic jerks (MJ), and decreased the seizure severity and mortality compared with the vehicle-treated animals in PTZ seizure model. The incidence of generalized clonic convulsions (stage 4) disappeared at doses of both 10 and 20 mg/kg.
Animal Model:ICR male mice (25-28 g, 10-12 in each group)[3]
Dosage:2, 5 and 10 mg/kg
Administration:Orally (p.o.), once, 15 min and 1 h prior to pentobarbital injection
Result:Significantly decreased locomotor activity at 10 mg/kg. Increased NREM and total sleep, but decreased wakefulness.