| CAS NO: | 10078-25-8 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 10078-25-8 |
| 别名 | 奋乃静亚砜 |
| Canonical SMILES | O=S1C2=C(N(CCCN3CCN(CC3)CCO)C4=CC(Cl)=CC=C41)C=CC=C2 |
| 分子式 | C21H26ClN3O2S |
| 分子量 | 420 |
| 溶解度 | DMF: 3 mg/ml,DMSO: 2 mg/ml,Ethanol: 3 mg/ml,PBS (pH 7.2): insol |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Perphenazine sulfoxide is an active metabolite of the typical antipsychotic perphenazine .1It is formedviaoxidation of perphenazine. Perphenazine sulfoxide selectively binds to dopamine D2and α1-adrenergic receptors (α1-ARs) over α2-ARs (Kis= 5.9, 24, and 683 nM, respectively) in rat brain.2It increases thrombin-induced increases in phosphatidylinositol levels in isolated human platelets when used at a concentration of 5 µM.3 1.Hals, P.A., Hall, H., and Dahl, S.G.Phenothiazine drug metabolites: Dopamine D2 receptor, α1- and α2-adrenoceptor bindingEur. J. Pharmacol.125(3)373-381(1986) 2.Tharmapathy, P., Fukami, M.H., and Holmsen, H.The stimulatory effects of cationic amphiphilic drugs on human platelets treated with thrombinBiochem. Pharmacol.60(9)1267-1277(2000) |
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