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Inflammasome Inhibitor 4b
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Inflammasome Inhibitor 4b图片
CAS NO:2768759-64-2
包装:1mg
市场价:1330元

产品介绍
An inhibitor of NLRP3 inflammasome activation
Cas No.2768759-64-2
Canonical SMILESO=C(NS(=O)(C1=CC(C(C)(O)C)=CO1)=O)[N-]C2=CC(C)=CC(C)=C2.[Na+]
分子式C16H19N2O5S ? Na
分子量374.4
溶解度DMSO: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Inflammasome inhibitor 4b is an inhibitor of NOD-like receptor protein 3 (NLRP3) inflammasome activation.1It inhibits ATP-induced IL-1β release by 98.3% in LPS-primed mouse bone marrow-derived macrophages (BMDMs) when used at a concentration of 1 µM. Inflammasome inhibitor 4b (3 and 10 mg/kg) decreases paw swelling and mechanical hyperalgesia in a mouse model of gout induced by monosodium urate crystals.

1.Narros-FernÁndez, P., Chioua, M., Petcu, S.A., et al.Synthesis and pharmacological evaluation of new N-sulfonylureas as NLRP3 inflammasome inhibitors: Identification of a hit compound to treat goutJ. Med. Chem.65(8)6250-6260(2022)