包装 | 价格(元) |
10mM (in 1mL DMSO) | 电议 |
10mg | 电议 |
5-HT1AReceptor 7.63(pKi) | 5-HT2AReceptor 10.22(pKi) |
5-HT2BReceptor 10.44(pKi) | 5-HT2CReceptor 8.42(pKi) |
产品描述 | Pimethixene maleate is antihistamine and antiserotonergic compound, acts as an antimigraine agent.Pimethixene maleate is a highly potent antagonist of 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors, with pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively[1]. [1]. Schmitz B, et al. BF-1--a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs. Eur J Pharmacol. 2015 Mar 15;751:73-80. |