CaV1,3 antagonist-1

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CaV1,3 antagonist-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1391385-57-1

包装与价格：

包装	价格(元)
10mg	电议
25mg	电议

产品介绍

CaV1.3 antagonist-1 是一种有效且高度选择性的 CaV1.3 L 型钙通道拮抗剂，IC50 为 1.7 μM。CaV1.3 antagonist-1 对 CaV1.3 LTCC 的抑制比 CaV1.2 LTCC 强 600 倍以上。CaV1.3 antagonist-1 是一种环戊基衍生物，具有用于帕金森病研究的潜力。

Cas No.	1391385-57-1
分子式	C₁₇H₁₉ClN₂O₃
分子量	334.8
溶解度	DMSO : 100 mg/mL (298.69 mM; Need ultrasonic)
储存条件	4°C, protect from light
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	CaV1.3 antagonist-1 is a potent and highly selectiveCa_V1.3 L-type calcium channel (LTCC)antagonist with anIC₅₀of 1.7 μM. CaV1.3 antagonist-1 inhibits Ca_V1.3 LTCC >600-fold more potently than Ca_V1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the potential for Parkinson's disease research^[1]. CaV1.3 antagonist-1 (Compound 8; 5 μM) exhibits 31.2% and 4.4% inhibition for Ca_V1.3 and Ca_V1.2 channel current in HEK293 cells, respectively. This correlates with the results of the FLIPR assay^[1].