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Nav1,7-IN-3
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Nav1,7-IN-3图片
CAS NO:1788872-06-9
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Nav1.7-IN-3是选择性，有口服活性的电压门控钠离子通道 Nav1.7 抑制剂，IC50 为8 nM。CNS渗透能力有限。缓解疼痛。
Cas No.1788872-06-9
分子式C17H20ClFN4O2S2
分子量430.95
溶解度DMSO :< 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Pain relief. Limited CNS penetration[1].

Nav1.7-IN-3 (compound 5) shows excellent potency, selectivity, behavioral efficacy in a rodent pain model (30 mg/kg, oral, 35 minutes), and efficacy in a mouse itch model (30 mg/kg, oral, 30 minutes)[1].

[1]. Roecker AJ, et al. Discovery of selective, orally bioavailable, N-linked arylsulfonamide Nav1.7 inhibitors with pain efficacy in mice. Bioorg Med Chem Lett. 2017 May 15;27(10):2087-2093.